Scientific Support

Extracorporeal Shockwaves

High- and low energy shockwaves have been proven to work as a useful treatment in many different diseases. The underlying mechanism responsible for the broad variety of processes initiated (e.g. genexpression TGF-beta 1, neovascularization, anti-inflammatory response, up-regulation of PCNA), is known as cellular mechanical transduction. It is described as the ability to receive or rather forward mechanical input and to produce a biological answer. Not only over 80% of our cell parts are sensitive to mechanical stress but it has been shown, that physical input is able to activate our cells through mechanical transduction

Mechanical Transduction

“Note that there are many excellent reviews in the literature that focus on different types of cells, including cardiac fibroblasts (MacKenna et al., 2000), cardiac myocytes (Sadoshima and Izumo, 1997), smooth muscle cells (Osol, 1995), endothelial cells (Davies, 1995; Resnick and Gimbrone, 1995), bone cells (Duncan and Turner, 1995), lung cells (Liu and Post, 2000), and dermal fibroblasts (Silver et al., 2003a). Interested readers should consult these references for an in-depth understanding of the topic of cellular mechanotransduction mechanisms.” (Wang, 2006, p.1573)

Low energy shockwaves (evocell)​

“Low energy level shockwaves with low impulses showed positive stimulatory effects, whereas the high energy level with high impulses had significant inhibitory effects. At lower energy, up-regulation of proliferating cell nuclear antigen (PCNA), collagen type 1 & 3 and TGF-beta 1 gene expression were observed, followed by an increase in NO [nitric oxide, ed. note] production, TGFb1 and collagen synthesis.” (Orhan et al., 2004)